CJC-1295 with DAC

CJC-1295 with DAC is based on the first 29 amino acids of GHRH, with modifications that make the molecule more stable. The difference compared with the non-DAC variant lies in the Drug Affinity Complex: an addition that enables the molecule to bind to albumin in the blood.

Mechanism of action under investigation

Because it binds to albumin, CJC-1295 with DAC is broken down much more slowly, meaning that in studies it exhibits a much longer duration of action — days rather than hours. This makes it suitable for experiments in which a sustained, long-lasting GHRH signal is desired, in contrast to the short, pulsatile pattern of the non-DAC variant.

GHRH is the signal that triggers the pituitary gland to release growth hormone. This description relates to the mechanism of action as studied in research and does not constitute evidence of efficacy in humans.

The long duration of action also has implications for the experimental design: whereas a short-acting signal can be monitored on a pulse-by-pulse basis, a long-acting molecule requires measurements spanning several days. Researchers choose the approach that best suits the timescale of their research question.

CJC-1295 with DAC has been extensively studied in research into the GHRH signalling pathway, precisely because of its exceptionally long duration of action. It is often compared with the non-DAC variant to investigate the effect of duration of action on the regulation of growth hormone.

• Research focus: long-term activation of the GHRH receptor.
• Research focus: the effect of albumin binding on the duration of action.
• Research focus: comparison with short-acting variants (preclinical).

Status and context

CJC-1295 with DAC is not authorised as a medicinal product and is supplied solely as research material. In the context of sport, GHRH analogues are on the World Anti-Doping Agency’s (WADA) Prohibited List. For a related research compound, see also Tesamorelin. When conducting research, always document the purity and batch number.

The comparison between the DAC and non-DAC variants is, in itself, a valuable research model: it demonstrates how a single modification — albumin binding — radically alters the duration of action of a peptide. A pure starting material, documented for each batch, is a prerequisite for reliable comparisons.

CJC-1295 with DAC is supplied as a lyophilised powder and reconstituted in the laboratory using bacteriostatic water. The steps below describe only the laboratory procedures for research purposes.

1. 1Allow the vial and the bacteriostatic water to reach room temperature.
2. 2Wipe the rubber stoppers of both vials with an alcohol wipe.
3. 3Allow the bacteriostatic water to run slowly down the side of the vial; do not direct it straight onto the powder.
4. 4Gently swirl the vial until everything has dissolved; do not shake.
5. 5Store the solution in the fridge and label it with the date and batch number.

You can find supplies such as bacteriostatic water, insulin syringes and alcohol wipes under ‘Lab & Accessories’. This is a laboratory instruction and does not constitute dosage advice for consumption.

Choose the right option

Decide in advance whether a long-lasting, continuous signal (with DAC) or a short, pulsed signal (no DAC) is appropriate for your research question. That choice determines the experimental design and the way in which you plot your measurements over time.

When dealing with a long-acting molecule, plan your measurement points in advance so that you can monitor its full duration of action.

Store CJC-1295 with DAC in powder form in a cool, dark place to ensure maximum stability.

Practical storage tips

• Powder form: freezer (-20 °C) for long-term storage; fridge (2–8 °C) for short-term storage.
• After reconstitution: store refrigerated (2–8 °C) and use within a few weeks.
• Avoid direct light, heat and repeated temperature changes.
• Write the reconstitution date and batch number on the vial.

Careful storage preserves the purity of the research material.

Stable, cold storage facilitates reliable comparisons between experiments.